Houston Astros vs Philadelphia Phillies is a regular-season Major League Baseball game played at Citizens Bank Park in Philadelphia. The contest pits the home club, the Philadelphia Phillies, against the Houston Astros as part of the MLB 2026 season and brings an interleague matchup between National and American League opponents to the South Philadelphia Sports Complex. The game draws local and traveling fans to a major-league ballpark and features rosters from two high-profile MLB franchises.